SAINT

4/03(목) 전문가초청특강은 KAIST 박윤수 교수님을 모시고 진행합니다.

관심있는 분들의 많은 참석 부탁드립니다.

ㅁ주제: Photocatalytic Single-atom Editing

ㅁ일시: 04/03(목) 16:00

ㅁ장소: 제2종합연구동 83188호

ㅁ약력:

○ Education
   - Ph.D. in Chemistry, March 2014 – February 2019
              Advisor: Sukbok Chang, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea
              Dissertation: Mechanism-Driven Approaches to Site- and Enantioselective C–H Amidation Reactions
                                    by Developing Robust Nitrene Precursors
   - B.S. in Chemistry, February 2010 – February 2014,  Summa cum laude, KAIST, Daejeon, Korea
   - Exchange Student in Chemistry, October 2012 – February 2013, Technical University of Munich, Munich, Germany
○  Academic Experience
   - Assistant Professor, January 2022 – to date
                  Department of Chemistry, KAIST, Daejeon, Korea
  - Postdoctoral Research Associate, October 2019 – November 2021
                   Advisor: Paul J. Chirik, Princeton University, New Jersey, United States
  - Research Fellow, March 2019 – September 2019
                   Center for Catalytic Hydrocarbon Functionalizations, Institute for Basic Science (IBS), Daejeon, Korea
  - Visiting Research, January 2017 – March 2017
                  Advisor: Matthew S. Sigman, University of Utah, Utah, United States

ㅁ초록:

A single atom in aromatic heterocycles determines the unique properties and activity of
functional molecules, such as natural products and pharmaceutical drugs. However, systematic
evaluation of the single-atom effect has posed a synthetic challenge, and multi-step procedures have
been inevitable based on classical approaches. In this talk, I will present single-step, catalytic
protocols that directly exchange a single atom in an aromatic heterocycle with the isoelectronic
congeners under redox-neutral conditions. Broad compatibility was observed with various substrates
and nucleophiles that contain common functional groups encountered in the drug discovery process.
The applicability in late-stage functionalization was studied, where synthetic short-cuts en route to the
heterocyclic analogs were demonstrated. Mechanistic analyses suggested that radical-based ringopening
was initiated by polarity inversion, and further spin delocalization kinetically unlocks the
underdeveloped pathway of direct atom exchange.