SAINT

05/08(목) 전문가초청특강은 POSTECH 김현우 교수님을 모시고 진행합니다.

관심있는 분들의 많은 참석 부탁드립니다.

ㅁ주제: Electrochemistry Opens New Possibilities in Unsaturated C-C Bond Functionalization

ㅁ일시: 05/08(목) 16:00

ㅁ장소: 제2종합연구동 83188호

ㅁ약력:

  ○ EDUCATION
     Korea Advanced Institute of Science and Technology (KAIST), Daejeon
     Ph.D. in Organic Chemistry (Organometallic Catalysis)          2013–2018
     Advisor: Prof. Sukbok Chang
     Korea Advanced Institute of Science and Technology (KAIST), Daejeon
     B.S. in Chemistry                                                   2009–2013
 ○ AWARDS & HONORS
     Asian Core Program (ACP) on Cutting-Edge Organic Chemistry Lectureship Award, 2024
     Samsung Science & Technology Foundation Awardee in Chemistry, 2024
     Thieme Chemistry Journals Award, 2024
     Asian Core Program (ACP) on Cutting-Edge Organic Chemistry Lectureship Award, 2023
     The 6th Toray Research Grant for Young Investigator, 2023
     The 13th POSCO Science Fellowship, 2022
     Excellent Thesis Award, KAIST, 2018

ㅁ초록:

Alkene functionalization plays a pivotal role in expanding the repertoire of synthetic methods and
enhancing the complexity of organic compounds providing an “escape from flatland”.
Recent advances include the development of regioselective alkene hydrofunctionalization, with
metal-catalyzed hydrogen atom transfer (MHAT) emerging as a key strategy for adding structural
diversity from alkene starting materials. In the first part of the talk, the strategic application of
electricity in cobalt-MHAT catalysis will be discussed, which could provide a new way for the reactive
intermediate to outcompete undesired side reactions. Moreover, this electrocatalytic platform has the
potential to function as an efficient bypass for unfavorable intramolecular reactions which possess
inherent kinetic challenges.
In the second part, difluoromethylative functionalization of unsaturated C−C bonds under
electrochemical conditions will be discussed. Despite the high prevalence and importance of vicinal
hydrogen bond donors in pharmaceutical agents, a general synthetic method for doubly
difluoromethylated compounds remains extremely rare. By leveraging electrochemistry to oxidize
Zn(CF2H)2(DMPU)2−a conventionally utilized anionic transmetalating source−we paved a way to
utilize it as both CF2H radical and anion source to deliver CF2H groups in both terminal and internal
position of alkenes, thereby granting access to doubly-difluoromethylated alkanes.
Finally, a new redox strategy that obviates the need for redox-mediators, leveraged by direct
photoactivation of substrate for chemical reactions followed by the electrochemical oxidation of
photon-induced intermediates, will be discussed.