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  • LIM, YONGTAIK 홈페이지 바로가기

Research Interest

Immunobioengineering for Cancer Immunotherapy 
Engieered Biomaterials for the Control of Immunity 
Biomaterials-based molecular imaging contrast agents

Journal Article

  • (2022)  Nanoparticle-based delivery strategies of multifaceted immunomodulatory RNA for cancer immunotherapy.  JOURNAL OF CONTROLLED RELEASE.  343, 
  • (2021)  The potential adjuvanticity of cavant®soe for foot-and-mouth disease vaccine.  VACCINES.  9,  10
  • (2021)  Therapeutic efficacy of cancer vaccine adjuvanted with nanoemulsion loaded with TLR7/8 agonist in lung cancer model.  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.  37, 
  • (2021)  Self-assembled hyaluronic acid nanoparticles for osteoarthritis treatment.  BIOMATERIALS.  275, 
  • (2021)  Molecular and Macroscopic Therapeutic Systems forCytokine-Based Cancer Immunotherapy.  Advanced therapeutics.  2100026
  • (2020)  Chemical Strategies to Enhance the Therapeutic Efficacy of Toll-like Receptor Agonist Based Cancer Immunotherapy.  ACCOUNTS OF CHEMICAL RESEARCH.  53,  10
  • (2020)  A three-dimensional hyaluronic acid-based niche enhances the therapeutic efficacy of human natural killer cell-based cancer immunotherapy.  BIOMATERIALS.  247, 
  • (2019)  Improved Sensitivity of Intramolecular Strand Displacement Based on Localization of Probes.  ANALYTICAL CHEMISTRY.  91,  23
  • (2019)  Lyophilizable and Multifaceted Toll-like Receptor 7/8 Agonist-Loaded Nanoemulsion for the Reprogramming of Tumor Microenvironments and Enhanced Cancer Immunotherapy.  ACS NANO.  13,  11
  • (2019)  A Designer Scaffold with Immune Nanoconverters for Reverting Immunosuppression and Enhancing Immune Checkpoint Blockade Therapy.  ADVANCED MATERIALS.  31,  42
  • (2019)  Syringeable immunotherapeutic nanogel reshapes tumor microenvironment and prevents tumor metastasis and recurrence.  NATURE COMMUNICATIONS.  10, 
  • (2019)  Topological Transformation-Based Nanobarcoding for Detection and Enumeration of MicroRNAs and Single Nucleotide Polymorphism.  Advanced Biosystems.  3,  7
  • (2019)  Protein Nanoparticle Fabrication for Optimized Reticuloendothelial System Evasion and Tumor Accumulation.  LANGMUIR.  35,  11
  • (2019)  Nanoengineered Immune Niches for Reprogramming the Immunosuppressive Tumor Microenvironment and Enhancing Cancer Immunotherapy.  ADVANCED MATERIALS.  31,  34
  • (2018)  Targeted cellular delivery of robust enzyme nanoparticles for the treatment of drug-induced hepatotoxicity and liver injury.  ACTA BIOMATERIALIA.  81, 
  • (2018)  Degradation-Regulatable Architectured Implantable Macroporous Scaffold for the Spatiotemporal Modulation of Immunosuppressive Microenvironment and Enhanced Combination Cancer Immunotherapy.  ADVANCED FUNCTIONAL MATERIALS.  28,  47
  • (2018)  Enhanced Cancer Vaccination by In Situ Nanomicelle-Generating Dissolving Microneedles.  ACS NANO.  12,  10
  • (2018)  Implantable Synthetic Immune Niche for Spatiotemporal Modulation of Tumor-Derived Immunosuppression and Systemic Antitumor Immunity: Postoperative Immunotherapy.  ADVANCED MATERIALS.  30,  18
  • (2017)  Fluorescence-coded DNA Nanostructure Probe System to Enable Discrimination of Tumor Heterogeneity via a Screening of Dual Intracellular microRNA Signatures in situ.  SCIENTIFIC REPORTS.  7, 
  • (2017)  Aminated nanomicelles as a designer vaccine adjuvant to trigger inflammasomes and multiple arms of the innate immune response in lymph nodes.  INTERNATIONAL JOURNAL OF NANOMEDICINE.  12,  n


  • (2021)  Design of Nanostructure Materials to Modulate Immunosuppressive Tumour Microenvironments and Enhance Cancer Immunotherapy.  Springer Nature.  Lead author

Patent/Intellectual Property

  • 재구성 인공 암세포, 이의 제조방법, 및 이를 포함하는 항암조성물.  10-2017-0000357.  20180523.  KOREA, REPUBLIC OF
  • 폴리감마글루탐산 함유 하이드로겔 및 이를 포함하는 의료용 접착제 및 지혈제.  10-2016-0026130.  20180427.  KOREA, REPUBLIC OF
  • 약물 전달용 조성물 및 이의 제조방법.  10-2016-0116955.  20171201.  KOREA, REPUBLIC OF
  • 약물전달 조성물, 및 감염질환 진단 및 치료용 조성물.  10-2015-0050833.  20161007.  KOREA, REPUBLIC OF
  • 암 백신 조성물 및 이의 제조 방법.  10-2015-0050843.  20160804.  KOREA, REPUBLIC OF
  • 생체친화성 음이온 고분자 기반 약물 전달용 조성물 및 이의 제조 방법.  10-2014-0112655.  20160802.  KOREA, REPUBLIC OF
  • 아주번트 조성물 및 백신 조성물의 제조 방법.  10-2015-0073826.  20160215.  KOREA, REPUBLIC OF
  • 면역보조제 및 이를 포함하는 백신 조성물.  10-2014-0195268.  20160112.  KOREA, REPUBLIC OF
  • 면역자극 조성물, 이의 제조 방법, 및 이를 포함하는 면역요법 조성물.  10-2014-0195270.  20160112.  KOREA, REPUBLIC OF
  • 아주번트 조성물, 이의 제조 방법, 및 이를 포함하는 백신 조성물.  10-2014-0193994.  20160112.  KOREA, REPUBLIC OF
  • 아주번트 조성물, 이의 제조방법, 및 이를 포함하는 백신 조성물.  10-2014-0195269.  20151210.  KOREA, REPUBLIC OF
  • 온도감응형 이온성 복합체, 이의 제조 방법, 및 이를 포함하는 생분해성 조성물.  10-2014-0107045.  20151116.  KOREA, REPUBLIC OF
  • 중-대동물 수술가이드용 근적외선 형광 영상장비 및 이를 이용한 이미지화 및 수술가이드 방법.  1020130015119.  20150429.  KOREA, REPUBLIC OF
  • 활성물질을 담지할 수 있는 표면 딤플구조를 갖는 미립자 및 그 제조방법.  1020130046966.  20141216.  KOREA, REPUBLIC OF
  • 음이온성 고분자와 양이온성 고분자 이온복합체 기반 고감도 자기공명영상 나노조영제 및 이의 제조방법(Sensitive MRI Contrast Nano Agents Based Ionic Complex Containing Anionic and Cationic Polymer and Preparing Method Thereof).  10-2011-0031665.  20140515.  KOREA, REPUBLIC OF
  • 항체와 나노입자를 세포 내로 동시에 전달할 수 있는다기능성 단백질(Multifunctional Protein Simultaneous Delivering Antibodies and Nanoparticles).  10-2007-0074759.  20091102.  KOREA, REPUBLIC OF

Conference Paper

  • (2021)  Modulation of Tumor Microenvironment by a Designer Scaffold with Immune Checkpoint Blockade Enhance Cancer Immunotherapy.  2021년 고분자학회 춘계학술대회.  KOREA, REPUBLIC OF
  • (2021)  Engineered Macrophage via Click Chemistry Enhances Tumor Targeting and Remodels Immunosuprressive Tumor Microenvironment.  2021년 한국고분자학회 춘계학술대회.  KOREA, REPUBLIC OF
  • (2020)  Synthetic Immune Niches for Cancer Immunotherapy.  Internationa annual meeting of Korean Tissue Engineering and Regenerative Medicine Society.  KOREA, REPUBLIC OF
  • (2020)  Reprogramming of immunosuppressive tumor microenvironments by multifunctional nanoemulsion and enhance immune checkpoint blockade therapy.  AACR2020.  UNITED STATES
  • (2019)  Synthetic Immune Niches for the Modulation of Immunosuppressive Tumor Microenvironments and Enhancing Cancer Immunotherapy.  종양이형성 및 네트워크 제어 연구센터 2019 연례 심포지엄.  KOREA, REPUBLIC OF
  • (2019)  Synthetic Immune Niches for the Modulation of Tumor Immunosuppressive Microenvironments.  2019 KSMI-KSNM Integration Event Symposium on Molecular Imaging and Nanomedicine.  KOREA, REPUBLIC OF
  • (2019)  Toll-Like receptor 7/8 agonist-loaded Nanoemulsion Vaccine Adjuvant for the Enhanced Cancer Immunotherapy.  2019 Modern Vaccines Adjuvants & Delivery systems.  SWITZERLAND
  • (2019)  Nanoengineered platforms to modulate tumor immune microenvironments.  2019 UKC.  UNITED STATES
  • (2018)  Beyond Adjuvants: Vaccines for Cancer Immunotherapy and Infectious Disease.  International Society for VACCINES 2018 congress.  UNITED STATES
  • (2018)  Degradation-regulatable architectured implantable macroporous scaffold for the spatiotemporal modulation of immunosuppressive microenvironment and enhanced combination cancer immunotherapy.  Fourth International Cancer lmmunotherapy Conference..  UNITED STATES
  • (2018)  Implantable Synthetic Immune Hydrogel for Spatiotemporal Modulation of Tumor-derived Immunosuppression and Systemic Antitumor Immunity.  Fourth International Cancer lmmunotherapy Conference.  UNITED STATES
  • (2018)  Aminated Nanomicelles as Vaccine Adjuvants Induce Inflammasomes and The Innate Immune Response in Lymph nodes.  2018년 대한면역학회 춘계학술대회.  KOREA, REPUBLIC OF
  • (2018)  Implantable Synthetic Immune Hydrogel for Spatiotemporal Modulation of Tumor-derived Immunosuppression and Systemic Antitumor Immunity.  2018년 대한면역학회 춘계학술대회.  KOREA, REPUBLIC OF
  • (2018)  Synthetic vaccine nanoparticles target to lymph node triggering enhanced innate and adaptive antitumor immunity.  Keystone symposia Cancer Immunotherapy:Combinations.  CANADA
  • (2017)  Expeditious detection of hypoxic tumor microenviroments by fluorophore loaded enzyme-responsive nanoparticles.  THIRD CRI-CIMT-EATI-AACR INTERNATIONAL Cancer Immunotherapy Conference.  GERMANY
  • (2017)  Enhancement of innate and adaptive antitumor immunity by lymph node targeting with synthetic nanoparticle vaccine.  THIRD CRI-CIMT-EATI-AACR INTERNATIONAL Cancer Immunotherapy Conference.  GERMANY
  • (2017)  Cancer Immunotherapy based on Engineered Nanomaterials.  제53회 한국진공학회 하계정기학술대회 (한국진공학회보).  KOREA, REPUBLIC OF
  • (2017)  Immune Complexes Mimicking Synthetic Vaccine Nanoparticles for generating Dendritic Cells with Enhanced Cancer Immunotherapy.  5th International Conference Cancer Immunotherapy & Immunomonitoring (CITIM).  CZECH REPUBLIC
  • (2017)  Nanoliposomes Reconstituted from Tumor Cell Membranes and Lipid-based Adjuvants for image guided Cancer Immunotherapy.  5th International Conference Cancer Immunotherapy & Immunomonitoring (CITIM).  CZECH REPUBLIC
  • (2017)  Engineered Nanomaterials Reshaping Immune Response for Antitumor and Antiviral Immunity.  2017 한국생물공학회 춘계학술발표대회 및 국제심포지엄.  KOREA, REPUBLIC OF