• Bio/Immunoengineering for Cancer Immunotherapy
• Engineering Design of Immunomodulatory Agents
• Engineering Design of Drug Delivery Systems

• Ph.D., Department of Bio and Chemical Engineering, KAIST (2002)
• M.S., Department of Chemical Engineering, KAIST (1998)
• B.S., Department of Chemical Engineering, Sogang University (1996)

• Professor (2014–Present), Sungkyunkwan University, SKKU Advanced Institute of Nano Technology (SAINT) / Department of Nano Engineering / Department of Chemical Engineering
• Associate Professor (2009–2013), Department of Analytical Science and Technology (GRAST), Chungnam National University
• Senior Researcher (2005–2009), BioNano Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)
• Senior Researcher (2003–2004), Bio-Device Team, Electronics and Telecommunications Research Institute (ETRI)
• Postdoctoral Researcher (2002–2003), Division of Hematology and Oncology, Harvard Medical School

• (2025) Multiscale dynamic immunomodulation by a nanoemulsified Trojan-TLR7/8 adjuvant for robust protection against heterologous pandemic and endemic viruses. CELLULAR & MOLECULAR IMMUNOLOGY. 22, 9
• (2025) γδ+ T-cell-derived IL-17A stimulates airway epithelial/stromal cells to secrete G-CSF, promoting lung-specific pathogenic Siglec-F+ neutrophil development in PPE-induced emphysema. CELLULAR & MOLECULAR IMMUNOLOGY. 22, 7
• (2025) Kinetically activating nanovaccine mimicking multidimensional immunomodulation of natural infection for broad protection against heterologous viruses in animal models. NATURE COMMUNICATIONS. 16, 1
• (2025) Spatiotemporal Dynamic Immunomodulation by Infection-Mimicking Gels Enhances Broad and Durable Protective Immunity Against Heterologous Viruses. ADVANCED SCIENCE.
• (2024) STING-activating dendritic cell-targeted nanovaccines that evoke potent antigen cross-presentation for cancer immunotherapy. BIOACTIVE MATERIALS. 42
• (2024) Virulence-Free Reconstituted Synthetic Nanopathogen Empowered by Timely-Activating TLR Agonist Promotes Heterologous Cancer Immunotherapy with Depletion of Tumor-Specific Treg Cells. ADVANCED FUNCTIONAL MATERIALS. 35, 1
• (2024) 3D Scaffold-Based Culture System Enhances Preclinical Evaluation of Natural Killer Cell Therapy in A549 Lung Cancer Cells. ACS Applied Bio Materials. 7, 11
• (2024) Transformable Gel-to-Nanovaccine Enhances Cancer Immunotherapy via Metronomic-Like Immunomodulation and Collagen-Mediated Paracortex Delivery. ADVANCED MATERIALS. 36, 48
• (2024) A biospecies-derived genomic DNA hybrid gel electrolyte for electrochemical energy storage. PNAS NEXUS. 3, 6
• (2024) Bioconjugated Antibody-Trojan Immune Converter Enhance Cancer Immunotherapy with Minimized Toxicity by Programmed Two-Step Immunomodulation of Myeloid Cells. ADVANCED HEALTHCARE MATERIALS. 13, 27
• (2024) Molecular Masking of Synthetic Immunomodulator Evokes Antitumor Immunity With Reduced Immune Tolerance and Systemic Toxicity by Temporal Activity Recovery and Sustained Stimulation. ADVANCED MATERIALS. 36, 9
• (2023) Nanoengineered Macrophages Armed with TLR7/8 Agonist Enhance Remodeling of Immunosuppressive Tumor Microenvironment. SMALL. 20, 13
• (2023) ProLonged Liposomal Delivery of TLR7/8 Agonist for Enhanced Cancer Vaccine. VACCINES. 11, 9
• (2023) Kinetics reshape antitumor immunity: Timing, duration, and combination are of importance for successful cancer immunotherapy. CLINICAL AND TRANSLATIONAL MEDICINE. 13, 9
• (2023) Discovery of highly immunogenic spleen-resident FCGR3(+)CD103(+) cDC1s differentiated by IL-33-primed ST2(+) basophils. CELLULAR & MOLECULAR IMMUNOLOGY. 20, 7
• (2023) Nanoengineered drug delivery in cancer immunotherapy for overcoming immunosuppressive tumor microenvironment. DRUG DELIVERY AND TRANSLATIONAL RESEARCH. 13, 7
• (2023) Discovery of highly immunogenic spleen-resident FCGR3+CD103+ cDC1s differentiated by IL-33-primed ST2+ basophils. CELLULAR & MOLECULAR IMMUNOLOGY. 20, 7
• (2023) Protective Efficacy and Immunogenicity of Rv0351/Rv3628 Subunit Vaccine Formulated in Different Adjuvants Against Mycobacterium tuberculosis Infection. IMMUNE NETWORK. 23, 2
• (2023) A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion. NATURE NANOTECHNOLOGY. 18, 4
• (2022) Fabrication of Drug-Loaded Calcium Phosphate Nanoparticles: An Investigation of Microbial Toxicity. JOURNAL OF CLUSTER SCIENCE. 33, 5

• (2021) Design of Nanostructure Materials to Modulate Immunosuppressive Tumour Microenvironments and Enhance Cancer Immunotherapy. Springer Nature. First Author

• CRYOGEL SCAFFOLD CAPABLE OF CONTROLLING DEGREE OF DEGRADATION AND SOFT BIO-INTEGRATED DEVICE IN WHICH DRUG MODULATING IMMUNOSUPPRESSIVE ACTION IN SOLID MICROENVIRONMENT IS LOADED IN SAME SCAFFOLD. 16/954,324. Jan 12, 2023, United States
• Conjugate of Toll-Like Receptor 7 or 8 Agonist and Cholesterol, and Uses Thereof. Application No. 10-2020-0014775, Nov 2, 2021, Republic of Korea
• Reversible Gel for Parenteral Drug Delivery Containing Non-Concentric Multi-Nanodomain Vesicles and Nanoliposomes, and a Drug Delivery Composition Comprising the Same. Application No. 10-2020-0008381, Oct 12, 2021, Republic of Korea
• Pharmaceutical Composition for Cancer Treatment Comprising an In Vivo Cell-Injection Chip as an Active Ingredient. Application No. 10-2019-0160276, Jul 21, 2021, Republic of Korea
• Cryogel Scaffold with Controllable Degradability and a Soft Bio-Implantable Device Loaded with a Drug That Regulates Immunosuppressive Action in the Solid Tumor Microenvironment. Application No. 10-2018-0143015, Mar 9, 2021, Republic of Korea
• Thermosensitive Ionic Composite, Preparing Method Thereof, and Biodegradable Composition Containing the Same. Application No. 14/828,876, Aug 28, 2018, United States
• Reconstituted Artificial Cancer Cells, Methods for Preparing the Same, and Anticancer Compositions Comprising the Same. Application No. 10-2017-0000357, May 23, 2018, Republic of Korea
• Poly-Gamma-Glutamic Acid-Containing Hydrogel and Medical Adhesive and Hemostatic Agent Comprising the Same. Application No. 10-2016-0026130, Apr 27, 2018, Republic of Korea
• Drug Delivery Composition and Method for Preparing the Same. Application No. 10-2016-0116955, Dec 1, 2017, Republic of Korea
• Drug Delivery Composition, and Composition for Diagnosis and Treatment of Infectious Diseases. Application No. 10-2015-0050833, Oct 7, 2016, Republic of Korea
• Cancer Vaccine Composition and Method for Preparing the Same. Application No. 10-2015-0050843, Aug 4, 2016, Republic of Korea
• Biocompatible Anionic Polymer-Based Drug Delivery Composition and Method for Preparing the Same. Application No. 10-2014-0112655, Aug 2, 2016, Republic of Korea
• Adjuvant Composition and Method for Preparing a Vaccine Composition. Application No. 10-2015-0073826, Feb 15, 2016, Republic of Korea
• Immunoadjuvant and Vaccine Composition Comprising the Same. Application No. 10-2014-0195268, Jan 12, 2016, Republic of Korea
• Immunostimulatory Composition, Method for Preparing the Same, and Immunotherapeutic Composition Comprising the Same. Application No. 10-2014-0195270, Jan 12, 2016, Republic of Korea
• Adjuvant Composition, Method for Preparing the Same, and Vaccine Composition Comprising the Same. Application No. 10-2014-0193994, Jan 12, 2016, Republic of Korea
• Adjuvant Composition, Method for Preparing the Same, and Vaccine Composition Comprising the Same. Application No. 10-2014-0195269, Dec 10, 2015, Republic of Korea
• Thermosensitive Ionic Composite, Method for Preparing the Same, and Biodegradable Composition Comprising the Same. Application No. 10-2014-0107045, Nov 16, 2015, Republic of Korea
• Near-Infrared Fluorescence Imaging Device for Surgical Guidance in Medium-to-Large Animals, and Imaging and Surgical Guidance Methods Using the Same. Application No. 10-2013-0015119, Apr 29, 2015, Republic of Korea
• Microparticles Having a Surface Dimple Structure Capable of Loading Active Substances, and Method for Preparing the Same. Application No. 10-2013-0046966, Dec 16, 2014, Republic of Korea

• Full Member of Domestic and International Chemistry-Related Academic Societies (including the Korean Association of Immunologists, the Korean Society for Biomaterials, the Polymer Society of Korea, etc.)
• Academic Committee Member, Korean Association of Immunologists
• Editorial Board Member, International Scientific Journals

• (2024) Engineered Novel Vaccine Adjuvant System. 1st International Symposium of PRIDE Laboratory: Towards One Health—Innovations in Infection and Inflammation, Republic of Korea
• (2024) Dynamic Coordination of Innate Immune Stimuli by Nanoadjuvant Enhances Cancer Immunotherapy without Immune Exhaustion. Eighth CRI–ENCI International Cancer Immunotherapy Conference, United States
• (2024) Programmed Two-Step Activation of Myeloid Cells via Antibody–Adjuvant Conjugates Synergizes Immune Checkpoint Blockade Therapy with Minimized Systemic Toxicity. 8th CRI–ENCI International Cancer Immunotherapy Conference, United States
• (2024) Engineered Nano-Vaccines for Prolonged and Broad Protection against Heterologous Variants of SARS-CoV-2 and Influenza Virus. IBS–KAI–KSV Conferences on Infection and Immunity, Republic of Korea
• (2024) Dynamic Immune Modulation Empowered by Designer Biomaterials. WBC 2024, 12th World Biomaterials Congress, Republic of Korea
• (2023) Materials for Kinetic Immune Modulation Reshape Immunity. 2023 International Conference of the Korean Society of Pharmaceutical Science and Technology, Republic of Korea
• (2023) Immune Designer for Dynamic Tailoring of Innate Immunity. 2023 Fall Annual Meeting of the Polymer Society of Korea, Republic of Korea
• (2023) Dynamic Coordination of Innate Immunity for Enhanced Cancer Immunotherapy and Reduction of Immune Cell Exhaustion Using Kinetically Activating Nanoadjuvant. Seventh CRI–CIMT–EATI–AACR International Cancer Immunotherapy Conference, Italy
• (2023) Dynamic Coordination of Innate Immunity for Enhanced Cancer Immunotherapy and Reduction of Immune Cell Exhaustion Using Kinetically Activating Nanoadjuvant. KAI International Meeting 2023, Republic of Korea
• (2023) Time-Controlled Dendritic Cell Activation for Enhanced Cancer Immunotherapy. KAI International Meeting 2023, Republic of Korea
• (2023) Engineered Macrophages Anchored with Toll-Like Receptor 7/8 Agonist via Click Chemistry Enhance Antitumor Immunity. KAI International Meeting 2023, Republic of Korea
• (2023) Reprogramming the Tumor Microenvironment with Immunostimulators and Blockade of the SIRPα–CD47 Axis Enhances Antitumor Innate Immunity. KAI International Meeting 2023, Republic of Korea
• (2023) Designer Vaccine Adjuvants/Immunomodulators for Infectious Diseases. Joint Annual Conference of the Korean Society for Virology Research Groups, Republic of Korea
• (2022) Controlling Chemoimmunotherapy-Induced Immunosuppression by Assemblable Immune-Modulating Nanosuspension Combined with a Supra-Adjuvant. 2022 Fall Meeting and International Symposium of the Korean Society for Biotechnology and Bioengineering, Republic of Korea
• (2022) Novel Vaccine Adjuvants Empowered by Coded Signal Integration. Virus Research Forum, Republic of Korea
• (2022) Nanoengineered Synthetic Immune Niches for Enhanced Cancer Immunotherapy. 2022 Spring Polymer Conference, Republic of Korea
• (2021) Enhanced Anti-Cancer Effect of Toll-Like Receptor 7/8 Agonist-Loaded Nanoemulsion-Based Delivery in a Lung Cancer Model. Bio-Inspired Nanomaterials, Republic of Korea
• (2021) In Situ Scaffold-Forming Immunotherapeutic Nanogel Overcomes Post-Surgical Immunosuppressive Tumor Microenvironment and Generates Systemic Anti-Tumor Immunity. Bio-Inspired Nanomaterials, Republic of Korea
• (2021) Reshaping Treatment-Induced Immunosuppressive Tumor Microenvironment with Multifunctional Nanosuspension for Enhanced Chemo-Immunotherapy. Bio-Inspired Nanomaterials, Republic of Korea
• (2021) Nanoengineered Synthetic Immune Niches for the Modulation of Tumor Immunosuppressive Microenvironments in Cancer Immunotherapy. Nano Korea 2021, Republic of Korea