04/23 (목) 전문가초청특강은 이화여자대학교 최한솔 교수님을 모시고 진행합니다.

관심있는 분들의 많은 참석 부탁드립니다.

ㅁ주제: Nucleic Acids Molecular Engineering for Synthetic Biology and Emerging Non-Genomic
Applications

ㅁ일시: 04/23 (목) 16:00

ㅁ장소: 제2종합연구동 83188호

ㅁ약력: 

ㅁ초록:

Nucleic Acids (DNA/RNA) are often described as the programming language of life, encoding
the fundamental instructions that govern cellular function and biological systems. By altering
genetic sequences, it is possible to engineer biological systems with novel functionalities or to
develop therapeutic molecules with advanced properties. Beyond their natural roles, the high
programmability of nucleic acids, particularly their capacity for high throughput reading and
writing enables DNA to be repurposed as a versatile tool for a wide range of applications such as
DNA nanotechnology and DNA computing. In this talk, applications of nucleic acid molecular
engineering—including antibody discovery, protein sequencing, and DNA-based computing—
will be discussed. First, a method for efficiently managing highly diverse antibody encoding
DNA libraries is proposed. To handle the high complexity of DNA strands, a barcode-based
subset selection system at single nucleotide resolution, and a hierarchical data architecture are
introduced, along with a microchip-based automated retrieval system. Second, a high-throughput
single-molecule protein identification technology will be discussed. Protein fingerprinting can be
achieved by measuring the distances between adjacent specific amino acid residues using force
spectroscopy. To enhance the throughput of this approach, a single-molecule resolution nanopatterning
strategy is proposed to enable scalable force spectroscopy measurements and highly
parallel protein identification. Lastly, we explore DNA as a computing platform, including
systems that operate as band-pass filters and enable logic-gated computation. A system that
synthesizes DNA as an output in response to external temperature changes, and that implements
various combinational logic gates will be discussed.